Qualitative aspect of drug action - UK Essays.
Various applications of pA x measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA x measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in.
Generally, the essay is about trying to develop bioas- says into instruments for pharmacological analysis. Specifically, I want first to rerun the discovery and classification of histamine Hz-receptor antagonists and then to see how much that classification has been use- ful in analyzing the physiological control of gastric oxyncic cell secretion.
D ale and L aidlaw (1910, 1911) showed that histamine stimulates the smooth muscle of many tissues such as intestine, bronchioles, arterioles, uterus, and spleen. Moreover, although the actions of histamine on smooth muscle were studied at an early date, identification of the receptor involved had to await the development of specific antagonists.
Hypothermia is a frequent symptom of organophosphate insecticide poisoning in animals and man, and Meeter and Wolthuis (126) have shown that the hypothermic effect of several cholinesterase inhibitors can be blocked by atropine which is also capable of blocking the hypothermia induced by the intracerebral injection of oxotremorine and carbachol (127).
Its classification maps directly onto the recent, important and extensive, insights and developments in cardiac electrophysiology and pharmacology. The latter have now often succeeded in identifying particular arrhythmic phenotypes with abnormalities in particular ion channels, ion transporters and signalling agents that might offer real or potential therapeutic targets at the molecular level.
Abstract. Stimulation of phosphoinositide-specific phospholipase C (PLC) by carbachol, dopamine and serotonin was measured by supplying exogenous (3 H)phosphatidylinositol 4,5-bisphosphate to membranes prepared from human cortex dissected and frozen at autopsy.Subjects with Alzheimer's disease, Parkinson's disease or schizophrenia were compared to age-matched controls with no known.
Datura is a genus of nine species of poisonous Vespertine flowering plants belonging to the family Solanaceae. They are commonly known as thornapples or jimsonweeds but are also known as devil's trumpets (not to be confused with angel's trumpets, which are placed in the closely related genus Brugmansia).Other English common names include moonflower, devil's weed and hell's bells.